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J Antimicrob Chemother. Jul;66(7) doi: /jac/dkr Epub Apr Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model. Baines SD(1), Noel AR, Huscroft GS, Todhunter SL, O'Connor R, Hobbs JK, Freeman J. We examined the in vitro activity of linezolid against Clostridium difficile, including isolates with reduced susceptibility to metronidazole or vancomycin. The MIC at which 50% of the isolates were inhibited (MIC50) and MIC90 were and 2 μg/ml, respectively (range, to 4 μg/ml).