Metformin and stomach cancer

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Metformin may inhibit gastric cancer development and progression by inhibiting HIF1α/PKM2 signaling [27]. The findings of epidemiological studies indicate that patients with T2DM who are treated with metformin have a lower risk of GC than patients who are not treated with metformin. However, the results. Two meta-analyses explored the incidence of gastric cancer in people with type 2 diabetes in case-control and cohort studies [8, 9]. A slight increase in the incidence of gastric cancer was reported, although the risk seems to be affected by sex. Women with diabetes showed an 18% increase in risk.

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Previous study showed that metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling pathway [18]. However, its anti-metastatic effects and/or regulating EMT remain as an unresolved issue in gastric cancer. Here, we showed that metformin was a potential inhibitor of EMT in AGS gastric  ‎Abstract · ‎Introduction · ‎Materials and methods · ‎Discussion. Four studies, 2 RCTs (6, patients) [44] and 2 observational (, patients) [53,62] reported the association of metformin therapy with stomach cancer (Figure 4B). The meta-analysis of observational studies showed that the use of metformin was associated with a significant reduction in the risk of.

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