However, even short-term NSAID therapy is not without risk. Risk Factors for GI Bleeding, Ulceration, and Perforation. Patients with a prior history of peptic ulcer disease and/or GI bleeding who used NSAIDs had a greater than fold increased risk for developing a GI bleed compared to patients without these risk factors. Celebrex can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
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"Occasional, short-term use of the over-the-counter naproxen sodium dose as found in Aleve was not studied," said Andre Schmidt, vice president of U.S. Medical Affairs, Consumer Health, Bayer, maker of naproxen. He added that Aleve is safe and risk of a serious gastrointestinal side effect is rare when. Back in , a popular arthritis drug called Vioxx was pulled off the market when studies showed daily long-term use could increase the risk of heart attack, stroke and death. “This was one of the most important safety events really in recent medical history,” Dr. Steven Nissen of the Cleveland Clinic, one of.
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