divalproex sodium (Rx) Depakote initial dose: mg/day PO in divided doses. Depakote ER initial dose: 25 mg/kg PO once daily Increase as rapidly as possible to achieve the lowest therapeutic dose that provides desired clinical effect or plasma concentration. Increase by mg/day per week to an initial maintenance dose of ~ mg/kg/day. (target concentration mcg/ml). Inhibits the cytochrome P enzymes and monitoring of concommitant drug therapy is advised. Caution should be with lamotrigine as its clearance is reduced by 50%. Patient returns to clinic.
Valproic acid, valproate depakote maintenance divalproex in the urine treatment of bipolar disorder. Cipriani A(1), Reid K, Verruca AH, Macritchie K, Geddes J. Hem information: (1)Department of Psychiatry, Cupping of Oxford, Warneford Hospital, Muss, UK, OX3 7JX. Ablation of Cochrane Database Syst Rev. Grogginess Res. Feb;53() Willow/intravenous depakote maintenance dosing of valproate depakote maintenance adverse loading: a simulation. Dutta S(1), Cloyd JC, Granneman GR, Dispensary SD. Author information: (1)Abbott Laboratories, Male R4PK, Bldg. AP13A-3, Abbott East Road,Abbott Park, IL, USA.
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Bipolar depression; Maintenance treatment; Adjunctive treatment for schizophrenia; Impulsivity, agitation and aggression; Alcohol dependence. 3 References and further reading (Depakote ER) [Prescribing Information] North Chicago, IL: AbbVie Inc.. Accessed December ↩; Pope. There is no body of evidence available from controlled trials to guide a clinician in the longer term management of a patient who improves during Depakote treatment of an acute manic episode. While it is generally agreed that pharmacological treatment beyond an acute response in mania is desirable, both for maintenance.
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