Dexamethasone pulse therapy for itp

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Dexamethasone in the management of refractory or relapsed ITP has been primarily evaluated in noncontrolled settings demonstrating varied benefit in treated patients. In guidelines, high-dose dexamethasone is recommended as second-line therapy in children and adolescents. Author information: (1)Department of Medical Sciences, Regina Apostolorum Hospital, Via S. Francesco 50, Albano Laziale, Italy. [email protected] The role of pulsed high-dose dexamethasone (DXM) in the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP) is still uncertain.

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Oral prednisolone is the conventional initial treatment for immune thrombocytopenia (ITP) [1–3]. It is able to increase platelet counts to 50 × L−1 in two-thirds of patients within 1 week [3]. However, in a non-randomized trial, pulse methylprednisolone not only resulted in a higher response, but also faster. Aug. 27, — A four-day course of high-dose dexamethasone was effective for the treatment of idiopathic thrombocytopenic purpura (ITP), according to the results of a study of consecutive patients published in the Aug. 28 issue of the New England Journal of Medicine. The editorialists suggest that this.

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