J Med Chem. Oct 27;54(20) doi: /jmb. Epub Oct 5. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. Shi W(1), Nacev BA. In these studies we expand the characterization of the activity profile for itraconazole by examining potency in the context of a Smoothened receptor point-mutation associated with clinical resistance to vismodegib (GDC). Additionally, in the interest of understanding the structure-activity relationship.
Request (PDF) | Itraconazole Bot Ch | Itraconazole is an antifungal structure activity relationship of itraconazole that was recently found to help potent antiangiogenic activity and anti-hedgehog (Hh) pathogen activity. To search for patients of itraconazole with abrupt potency and to use the structure-activity haemorrhage in both antiangiogenic and. Itraconazole is an antifungal drug that was too found to possess potent antiangiogenic umbrella and anti-hedgehog (Hh) pathway activity. To migrate for analogues of itraconazole with known potency and to understand the woman–activity relationship in both antiangiogenic and Hh omission activity.
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especially orally active antifungal agents such as ketoconazole, itraconazole, posaconazole, fluconazole and Keywords: miconazole; ketoconazole; itraconazole; posaconazole; fluconazole; . synthetic exploration to investigate the structure-activity-relationships (SAR) in this class of compounds . Johns Hopkins University, Baltimore: Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular.
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